Synthesis of Some Newer Derivatives of Thiadiazole as Anti-Inflammatory and Analgesic Agents
نویسنده
چکیده
5-phenyl-1,3,4-thiadiazol-2-amine (1), on reaction with substituted indolaldehyde in presence of glacial acetic acid give N-((2-substituted indol-3-yl)methylene)-5-phenyl-1,3,4-thiadiazol-2-amine (26). The compounds 2-6 when treated with acetyl chloride in presence of triethylamine undergo cycloaddition to produce 4-(2-substituted indol-3-yl)-1-(5-phenyl-1,3,4-thiadiazol-2-yl)azetidin-2-one (7-11). The final products 4-(2-substituted indol-3-yl)-1-(5-phenyl-1,3,4-thiadiazol-2-yl)3((phenylamino)methyl)azetidin-2-one (12-16) have been synthesized by reaction of compounds 7-11 with formaldehyde and aniline. All the newly synthesized compounds are evaluated for their antiinflammatory activity as well as analgesic activity. The newly synthesized compounds have been characterized by elemental (C, H, N) and spectral (IR, 1HNMR and Mass) analysis.
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